Journal article
Integrated elemental analysis supports targeting copper perturbations as a therapeutic strategy in multiple sclerosis
JBW Hilton, K Kysenius, JR Liddell, SW Mercer, C Rautengarten, DJ Hare, G Buncic, B Paul, SS Murray, CA McLean, TJ Kilpatrick, JS Beckman, S Ayton, AI Bush, AR White, BR Roberts, PS Donnelly, PJ Crouch
Neurotherapeutics | ELSEVIER SCIENCE INC | Published : 2024
Abstract
Multiple sclerosis (MS) is a debilitating affliction of the central nervous system (CNS) that involves demyelination of neuronal axons and neurodegeneration resulting in disability that becomes more pronounced in progressive forms of the disease. The involvement of neurodegeneration in MS underscores the need for effective neuroprotective approaches necessitating identification of new therapeutic targets. Herein, we applied an integrated elemental analysis workflow to human MS-affected spinal cord tissue utilising multiple inductively coupled plasma-mass spectrometry methodologies. These analyses revealed shifts in atomic copper as a notable aspect of disease. Complementary gene expression a..
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Awarded by Trish Multiple Sclerosis Research Foundation
Funding Acknowledgements
The research was supported by funds from Multiple Sclerosis Research Australia, The Trish Multiple Sclerosis Research Foundation, The National Health and Medical Research Council, The Michael Hirshorn Medical Research Commercialisation Fund, and Perpetual Trustees (Margaret Dawn Marks Trust) . JBWH was a recipient of an Australian Postgraduate Award and the Nancy Frances Curry Scholarship. JRL was a recipient of an NHMRC Early Career Fellowship. PSD was a recipient of an Australian Research Council Future Fellowship (FT3) . DJH was a recipient of an NHMRC Industry Career Development Fellowship (CDF1) in partnership with Agilent Technologies. ARW was a recipient of an NHMRC Senior Research Fellowship. PJC was a recipient of an NHMRC Career Development Fellowship (CDF2, 1084927) .